Building Flexibility in a Rapidly Evolving Biotech Industry for
TriLink BioTechnologies
Pac Rim partnered with Level 10 to deliver a flexible mRNA and nucleic acid manufacturing environment designed for long-term adaptability.
TriLink BioTechnologies, a leader in nucleic acid and mRNA technology, needed a production facility that could adapt to the fast-changing demands of biopharmaceutical manufacturing. As a subcontractor to Level 10 Construction (L10), Pacific Rim Mechanical (Pac Rim) partnered with the project team to deliver a flexible, large-scale manufacturing environment initially developed to support Pfizer’s mRNA program—and ultimately designed for long-term adaptability across future biotech applications.
The facility was built to increase capacity, improve production readiness, and meet the evolving needs of high-purity manufacturing in an industry defined by speed, precision, and regulatory compliance.
Challenge
Biotech projects rarely stand still—and TriLink’s was no exception. The project needed a design with experience in solvent delivery and solvent waste systems. Pac Rim’s in-house design team was selected due to their breadth of experience in this field and the firms ability to fully own system outcomes (design + build).
Midway through construction, changes in validation scope required the solvent system to be redesigned and reinstalled. The existing building also presented structural challenges: it was not originally designed to support the weight and vibration of biotech-grade utilities. Roof and framing reinforcements were necessary to safely accommodate process piping, mechanical equipment, and clean utility systems.
As TriLink’s production goals shifted following the conclusion of the Pfizer agreement, the project team had to quickly adjust layouts, sequencing, and validation plans—without compromising schedule or quality.
Solution Delivered
Pacific Rim Mechanical applied a collaborative, design-build approach focused on flexibility and precision. The team implemented new process systems for Water for Injection (WFI), Reverse Osmosis/Deionized Water (RODI), Clean-in-Place (CIP), Steam-in-Place (SIP), solvent distribution, and critical gases including Clean Compressed Air (CDA), nitrogen, argon, and CO₂.
Prefabrication was used extensively, allowing utility racks and process piping assemblies to be built off-site for faster, cleaner installation in controlled environments. 3D modeling and BIM coordination brought all trades—mechanical, electrical, structural, and fire protection—together early to mitigate conflicts and ensure compliance with seismic and load-bearing standards.
Throughout construction, PRM maintained cGMP-level standards for documentation, cleanliness, and quality control. This disciplined approach allowed the project to adapt to ongoing design changes while keeping the facility on track for validation and future expansion.
Outcome
The completed facility gives TriLink BioTechnologies a modern, scalable foundation for future growth in the rapidly evolving biotech sector. Designed for flexibility and built for precision, the plant supports both current operations and new production opportunities in mRNA and nucleic acid therapies.
- Project Executive, TriLink BioTechnologies,
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